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As shown in Section “Riboflavin Ameliorates Oxidative Stress, Mitochondrial Dysfunction, and Neuroinflammation,” riboflavin has antioxidant properties and upregulates antioxidant enzymes especially SOD, also, supplementation with riboflavin will elevate the intra-mitochondrial FAD levels compensating for the decline in the capacity to assemble of dysfunctional mitochondrial complexes